R&D

NampEVA BioTherapeutics (NBT) LLC, has a very strong and robust Division of R&D for the commercialization of medicinal plants and herbs grown in Africa.

There are numerous medicinal plants and herbs currently grown in Africa that have not been commercialized. A few specific examples are:

Azadirachta indica

the juice is used to kill intestinal worms, is anti-bacterial, anti-fungal and anti-protozoal. The leaves have been used as insect repellents and for treating chicken pox. Known to cure muscular pains and various skin infections such as eczema, scabies, itching and diabetes.

Abrus precatorius

cures; known to be effective against snakebite, gonorrhea, lack of sexual desire in women.

Alchornea cordifolia

known to cure snakebite, malaria, ear infection, kidney disorders.

Aloe barbadensis (Aloe)

known to cures malaria, fever, skin diseases, stops bleeding, scar remover, de-wormer.

NBT’s R&D will implement new strategies of medicines development which is based on holistic approach and multi-target therapy associated with the synergy concept, evidences from modern OMICS research and verified results of clinical efficacy and safety of standardized herbal medicinal products. Importantly, NBT’s Founder, Prof. Dr. Alexzander Asea has additional extensive research expertise and has published extensively on plant-based therapies.

Prof. Asea, President & CEO’s References Supporting In-Depth Understanding of Plant-Based Therapies:

Uruena, C., Cifuentes, C., Castaneda, D., Arango, A., Kaur, P., Asea, A., Fiorentino, S. Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells. BMC Complement Altern Med. 2008;8:60. PubMed PMID: 19017389. Pubmed Central PMCID: 2613870. 10.1186/1472-6882-8-60
Panossian, A., Wikman, G., Kaur, P., Asea, A. Molecular chaperones as mediators of stress protective effect of plant adaptogens. In Heat Shock Proteins and Whole Body Physiology, eds. A Asea, BK Pedersen, series eds. A Asea, SK Calderwood. Dordrecht, The Netherlands: Springer. Vol. 5, 2010;5:351-364.
Panossian, A., Wikman, G., Kaur, P., Asea, A. Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells. Frontiers in neuroscience. 2012;6:6. PubMed PMID: 22347152. Pubmed Central PMCID: 3269752. 10.3389/fnins.2012.00006
Uruena, C., Mancipe, J., Hernandez, J., Castaneda, D., Pombo, L., Gomez, A., Asea, A., Fiorentino, S. Gallotannin-rich Caesalpinia spinosa fraction decreases the primary tumor and factors associated with poor prognosis in a murine breast cancer model. BMC Complement Altern Med. 2013;13:74. PubMed PMID: 23552194. Pubmed Central PMCID: 3626639. 10.1186/1472-6882-13-74
Hernandez, J. F., Uruena, C. P., Cifuentes, M. C., Sandoval, T. A., Pombo, L. M., Castaneda, D., Asea, A., Fiorentino, S. A Petiveria alliacea standardized fraction induces breast adenocarcinoma cell death by modulating glycolytic metabolism. J Ethnopharmacol. 2014 May 14;153(3):641-9. PubMed PMID: 24637191. 10.1016/j.jep.2014.03.013
Panossian, A., Wikman, G., Kaur, P., Asea, A. Adaptogens stimulate neuropeptide Y and Hsp72 expression and release in neuroglia cells. Frontiers in neuroscience. 2012;6:6. PubMed PMID: 22347152. Pubmed Central PMCID: 3269752. 10.3389/fnins.2012.00006.
Asea, A., Kaur, P., Panossian, A., Wikman, K. G. Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts. Phytomedicine. 2013 Nov 15;20(14):1323-9. PubMed PMID: 23920279. 10.1016/j.phymed.2013.07.001.
Rosas, P.C., Nagaraja, G.M., Kaur, P., Panossian, A., Wickman, G., Garcia, L.R., Al-Khamis, A.F., Asea, A. Insoluble aggregates produced in a novel transgenic human-proIAPP C. elegans model are attenuated by coexpression of human Hsp72. PLoS ONE 2016 Mar 9;11(3):e0149409. doi: 10.1371/journal.pone.0149409. eCollection 2016.
Asea, A., Calderwood, S.K., Kaur, P., eds. Heat Shock Protein and Plants, series eds. A. Asea, S.K. Calderwood. Dordrecht, The Netherlands: Springer Nature. Vol. 10, 2017, 344 pp. ISBN 978-3-319-46340-7.